High spontaneous activity of C-nociceptors in painful polyneuropathy
IP Kleggetveit, B Namer, R Schmidt, T Helås, M Rückel… - PAIN®, 2012 - Elsevier
Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We
investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to
identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous
pain and 8 polyneuropathy patients without spontaneous pain were investigated by routine
clinical methods. For a specific examination of nociceptor function, action potentials from
single C-fibres including 214 C-nociceptors were recorded by microneurography. Patients …
investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to
identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous
pain and 8 polyneuropathy patients without spontaneous pain were investigated by routine
clinical methods. For a specific examination of nociceptor function, action potentials from
single C-fibres including 214 C-nociceptors were recorded by microneurography. Patients …
